The Orgasm Shot® (O-Shot®) procedure is a very specific method of using blood-derived growth factors to rejuvenate the vagina to help relieve women with urinary incontinence and sex problems.
“Treatment is safe, effective, non-surgical, and nonhormonal option for women having stress incontinence, overactive bladder, lack of lubrication and sexual dysfunction, such as lack of libido, arousal or dyspareunia.” “PRP induces regrowth of new tissues by of the activation of pluripotent stem cells.” “It seems to last around 1-2 years.”
PRP is an innovative therapeutic modality, as it is affordable, simple, easily performed, and effective. It is also a noninvasive modality with promising results and no side effects. In the field of gynecology, the few studies that have been conducted are pilot studies, case series, and case reports. The risks of PRP therapy as infection, bleeding, and nerve damage, appear to be minimal.
PRP therapies aim to increase the self-healing ability of the human body due to the effects of high-concentration autologous growth factors applied to the tissue. PRP is a minimally invasive method, which is easy to apply and fast, and has almost no adverse effects owing to it being autologous. Administration to the lower anterior vaginal wall may improve female sexuality with high satisfaction.
When PRP is activated and injected into the anatomic areas involved in sexual responsiveness, growth factors and cytokines may cause differentiation of pluripotent stem cells resulting in neoangiogenesis, fibroblast growth, glandular proliferation (Skene’s glands), and new neuronal growth. In addition to increased blood flow, collagen and sensory nerve regrowth might relieve coital discomfort as well as enhance vaginal sensitivity.
PRP plugs persisted in an amniotic fluid for a median time of 7 weeks. PRP plugs also provided waterproof sealing of a fetoscopic membrane defect. Finally, PRP stimulated cell proliferation in a monolayer cell culture and provided a good matrix for cell proliferation and migration in amnion–chorion tissue explants.